Fall 2012 Internet2 Member Meeting

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Speaker Details

Kenneth Buetow

ORG Arizona State University Title BIO Dr. Buetow's multi-disciplinary scientific career has focused for more than 25 years on applying sophisticated computational technologies to solve major biomedical challenges, particularly the role of genetics in complex human diseases such as cancer. He currently serves as Director of Computational Sciences and Informatics within Arizona State University's (ASU) Complex Adaptive Systems Initiative (CASI). CASI applies systems approaches that leverage ASU's interdisciplinary research strengths to address complex global challenges. The Computational Sciences and Informatics program is developing and applying information technology to connect and enhance trans-disciplinary knowledge both within ASU and across the broader knowledge-generating ecosystem to address problems in biomedicine, the environment, and national security. Dr. Buetow also serves as a professor in ASU's School of Life Sciences, where his research group similarly applies systems approaches to increase our understanding of the genetics and genomics of complex phenotypes, such as cancer and obesity.

Dr. Buetow previously served as the Director of the Center for Biomedical Informatics and Information Technology within the National Institutes of Health's National Cancer Institute (NCI). In that capacity he initiated and oversaw the NCI's pioneering efforts to connect the global cancer community through community-developed, standards-based, interoperable informatics capabilities that enable secure exchange and use of biomedical data. Buetow designed and built one of the largest biomedical computing efforts in the world. He was responsible for coordinating biomedical informatics and information technology. The NCI center he led focused on speeding scientific discovery and facilitated translational research by coordinating, developing and deploying biomedical informatics systems, infrastructure, tools and data in support of NCI research initiatives. He is a member of the Internet2 Research Advisory Group on Life Sciences. In addition to service on numerous governing and advisory boards, Dr. Buetow has published more than 180 scientific papers. His recent honors and awards include becoming a Fellow of the American College of Medical Information (2010), NIH Director's Award (2009), NIH Award of Merit (2009), The Editor's Choice Award from Bio-IT World (2008), and The Federal 100 Award (2005). Dr. Buetow received a B.A. in biology from Indiana University in 1980 and a Ph.D. in human genetics from the University of Pittsburgh in 1985. Selected Recent Publications 1. Clifford, R.J., Zhang, J., Meerzaman, D.M., Lyu, M.-S., Hu, Y., Cultraro, C.M., Finney, R.P., Kelley, J.M., Efroni, S., Greenblum, S.I., Nguyen, C.V., Rowe, W.L., Sharma, S., Wu, G., Yan, C., Zhang, H., Chung,Y.-H., Kim, J.A., Park, N.H., Song, I.L. and Buetow, K.H. Genetic variations at loci involved in the immune response are risk factors for hepatocellular carcinoma (HCC) in a Korean population. Hepatology Volume 52, Issue 6, pages 2034-2043, December 2010. 2. Mullighan C.G, Zhang J., Kasper L.H., Lerach S., Payne-Turner D., Phillips L., Ma J., Buetow K.H., Pui C.H., Brindle P.K. and Downing J.R., CREBBP mutations in relapsed acute lymphoblastic leukaemia. Nature 2011 Mar 10;471(7337):235-9. 3. Hesse BW, Croyle RT, Buetow KH. Cyberinfrastructure and the biomedical sciences. Am J Prev Med. 2011 May;40(5 Suppl 2):S97-102. 4. Braun,R and Buetow, KH. Pathways of Distinction Analysis: a new technique for multi-SNP analysis of GWAS data. PLoS Genetics 2011 Jun;7(6):e1002101.. 5. Ambrose LF, Freedman J, Buetow K, Friend S, Schilsky RL. Using patient-initiated study participation in the development of evidence for personalized cancer therapy. Clin Cancer Res. 2011 Nov 1;17(21):6651-7. 6. Hu Y, Wu G, Rusch M, Lukes L, Buetow KH, Zhang J, Hunter KW. An Integrated Human/Mouse Cross-species Transcriptional Network Analysis of Metastatic Susceptibility. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3184-9. 7. Gegonne A, Tai X, Zhang J, Wu G, Zhu J , Yoshimoto A, Hanson J, Cultraro C, Chen QR, Guinter T, Yang Z, Hathcock K, Singer A, Rodriguez-Canales J, Tessarollo L, Mackem S, Meerzaman D, Buetow K, Singer D. General Transcription Factor TAF7 is Not Essential for Survival or Differentiation of Mature T Cells, Mol Cell Biol. 2012 Mar 12

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